p53 and Gli combine forces

Fairleigh Dickinson, Medco combine forces to modernize pharmacy practice.

Nanog, Gli, and p53: a new network of stemness in development and cancer.

Nanog and Hedgehog (HH) are both essential regulators of stemness by promoting self-renewal in embryonic stem cells, during early embryonal development (Mitsui et al, 2003) and in cancer cells (Jeter et al, 2009). Two groups have now shown that HH signalling regulates Nanog expression in neural stem cells in the adult brain and in brain tumours. In this issue of The EMBO Journal, Po et al (2010...

Mouse Thalamic Differentiation: Gli-Dependent Pattern and Gli-Independent Prepattern

Sonic hedgehog (Shh) signaling is essential for thalamic development. The Gli transcription factors act downstream of Shh - while Gli2 is the major activator (GliA), Gli3 acts primarily as a repressor (GliR). The thalamus is remarkable among dorsal structures because of its proximity to the mid-diencephalic organizer, a unique dorsal Shh source. This lends complexity to the interactions between...

How to combine and not to combine physics and metaphysics

In this paper I will argue that if physics is to become a coherent metaphysics of nature it needs an “interpretation”. As I understand it, an interpretation of a physical theory amounts to offering (1) a precise formulation of its ontological claims and (2) a clear account of how such claims are related to the world of our experience. Notably, metaphysics enters importantly in both tasks: in (1...

To Combine Forecasts or to Combine Information?

When the objective is to forecast a variable of interest but with many explanatory variables available, one could possibly improve the forecast by carefully integrating them. There are generally two directions one could proceed: combination of forecasts (CF) or combination of information (CI). CF combines forecasts generated from simple models each incorporating a part of the whole information ...